The functions and unique features of long intergenic non-coding RNA.
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ABSTRACT:
SUBMITTER: Ransohoff JD
PROVIDER: S-EPMC5889127 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
The functions and unique features of long intergenic non-coding RNA.
Ransohoff Julia D JD Wei Yuning Y Khavari Paul A PA
Nature reviews. Molecular cell biology 20171115 3
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine- ...[more]
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