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The functions and unique features of long intergenic non-coding RNA.

ABSTRACT: Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity through a diversity of mechanisms, highlighting our rapidly evolving understanding of the non-coding genome.

SUBMITTER: Ransohoff JD

PROVIDER: S-EPMC5889127 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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The functions and unique features of long intergenic non-coding RNA.

Ransohoff Julia D JD Wei Yuning Y Khavari Paul A PA

Nature reviews. Molecular cell biology 20171115 3

Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine- ...[more]

PMID: 29138516

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