Ontology highlight
ABSTRACT:
SUBMITTER: Kline JB
PROVIDER: S-EPMC5581011 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Kline James Bradford JB Kennedy Rina P RP Albone Earl E Chao Qimin Q Fernando Shawn S McDonough Jennifer M JM Rybinski Katherine K Wang Wenquan W Somers Elizabeth B EB Schweizer Charles C Grasso Luigi L Nicolaides Nicholas C NC
Oncotarget 20170707 32
Cancers employ a number of mechanisms to evade host immune responses. Here we report the effects of tumor-shed antigen CA125/MUC16 on suppressing IgG1-mediated antibody-dependent cellular cytotoxicity (ADCC). This evidence stems from prespecified subgroup analysis of a Phase 3 clinical trial testing farletuzumab, a monoclonal antibody to folate receptor alpha, plus standard-of-care carboplatin-taxane chemotherapy in patients with recurrent platinum-sensitive ovarian cancer. Patients with low ser ...[more]