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[11C]Cyanation of arylboronic acids in aqueous solutions.

ABSTRACT: A copper-mediated 11C-cyanation method employing arylboronic acids and [11C]HCN has been developed. This method was applied to the radiochemical synthesis of a wide range of aromatic 11C-nitriles in aqueous solutions. The use of readily accessible arylboronic acids as precursors makes this method complementary to the well-established 11C-cyanation methods that utilize aryl halide precursors.

SUBMITTER: Ma L

PROVIDER: S-EPMC5584069 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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[11C]Cyanation of arylboronic acids in aqueous solutions.

Ma Longle L Placzek Michael S MS Hooker Jacob M JM Vasdev Neil N Liang Steven H SH

Chemical communications (Cambridge, England) 20170605 49

A copper-mediated 11C-cyanation method employing arylboronic acids and [11C]HCN has been developed. This method was applied to the radiochemical synthesis of a wide range of aromatic 11C-nitriles in aqueous solutions. The use of readily accessible arylboronic acids as precursors makes this method complementary to the well-established 11C-cyanation methods that utilize aryl halide precursors. ...[more]

PMID: 28580477

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