Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida M
PROVIDER: S-EPMC5593935 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Yoshida Mari M Ishioka Yukichi Y Ozawa Takamasa T Okuyama Hirohisa H Iguchi Motofumi M Ota Takeshi T Ito Takaomi T Nagira Morio M Morita Atsushi A Tanaka Hidekazu H Naito Hisamichi H Kidoya Hiroyasu H Takakura Nobuyuki N
Scientific reports 20170911 1
Partner of sld five 1 (PSF1) is an evolutionary conserved DNA replication factor involved in DNA replication in lower species, which is strongly expressed in normal stem cell populations and progenitor cell populations. Recently, we have investigated PSF1 functions in cancer cells and found that PSF1 plays a significant role in tumour growth. These findings provide initial evidence for the potential of PSF1 as a therapeutic target. Here, we reveal that PSF1 contains an immunogenic epitope suitab ...[more]