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Design and Development of Novel 2-(Morpholinyl)-N-substituted Phenylquinazolin-4-amines as Selective COX-II Inhibitor.


ABSTRACT: BACKGROUND:A novel series of 2-(Morpholin-4-yl)-N-phenylquinazolin-4- amine derivatives were synthesized and confirmed with spectral and elemental techniques. METHODS:The compounds were tested for analgesic and anti-inflammatory activity by various pain models in rodents whereas the selectivity towards COX-2 receptor is determined by in vitro assay. RESULTS:Screening results of compounds exhibited comparable biological activity with that of standard compound Indomethacin used for study. Compound 5d was found to be significantly potent with respect to its anti-inflammatory and analgesic activity with substantial COX-II selectivity. CONCLUSION:In silico analysis by molecular docking and 3D-QSAR studies justifies activity profile of compound 5d, suggesting that it may have potential for further evaluation and development as lead molecule for therapy in pain management.

SUBMITTER: Dravyakar BR 

PROVIDER: S-EPMC6446527 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Design and Development of Novel 2-(Morpholinyl)-N-substituted Phenylquinazolin-4-amines as Selective COX-II Inhibitor.

Dravyakar Bhushan R BR   Khedekar Pramod B PB   Khan Tabassum T   Sherje Atul P AP   Patel Kavit N KN   Suvarna Vasanti V  

Anti-inflammatory & anti-allergy agents in medicinal chemistry 20190101 1


<h4>Background</h4>A novel series of 2-(Morpholin-4-yl)-N-phenylquinazolin-4- amine derivatives were synthesized and confirmed with spectral and elemental techniques.<h4>Methods</h4>The compounds were tested for analgesic and anti-inflammatory activity by various pain models in rodents whereas the selectivity towards COX-2 receptor is determined by in vitro assay.<h4>Results</h4>Screening results of compounds exhibited comparable biological activity with that of standard compound Indomethacin us  ...[more]

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