Ontology highlight
ABSTRACT:
SUBMITTER: Dravyakar BR
PROVIDER: S-EPMC6446527 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Dravyakar Bhushan R BR Khedekar Pramod B PB Khan Tabassum T Sherje Atul P AP Patel Kavit N KN Suvarna Vasanti V
Anti-inflammatory & anti-allergy agents in medicinal chemistry 20190101 1
<h4>Background</h4>A novel series of 2-(Morpholin-4-yl)-N-phenylquinazolin-4- amine derivatives were synthesized and confirmed with spectral and elemental techniques.<h4>Methods</h4>The compounds were tested for analgesic and anti-inflammatory activity by various pain models in rodents whereas the selectivity towards COX-2 receptor is determined by in vitro assay.<h4>Results</h4>Screening results of compounds exhibited comparable biological activity with that of standard compound Indomethacin us ...[more]