Ontology highlight
ABSTRACT:
SUBMITTER: Jiang H
PROVIDER: S-EPMC5603233 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Jiang Hong H Hegde Samarth S DeNardo David G DG
Cancer immunology, immunotherapy : CII 20170427 8
Tumor-associated fibrosis is characterized by unchecked pro-fibrotic and pro-inflammatory signaling. The components of fibrosis including significant numbers of cancer-associated fibroblasts, dense collagen deposition, and extracellular matrix stiffness, are well appreciated regulators of tumor progression but may also be critical regulators of immune surveillance. While this suggests that the efficacy of immunotherapy may be limited in highly fibrotic cancers like pancreas, it also suggests a t ...[more]