Ontology highlight
ABSTRACT:
SUBMITTER: Iversen R
PROVIDER: S-EPMC5603730 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Iversen Rasmus R Snir Omri O Stensland Maria M Kroll José E JE Steinsbø Øyvind Ø Korponay-Szabó Ilma R IR Lundin Knut E A KEA de Souza Gustavo A GA Sollid Ludvig M LM
Cell reports 20170901 10
Mucosal antigens induce generation of lamina propria plasma cells (PCs) that secrete dimeric immunoglobulin A (IgA) destined for transport across the epithelium. In addition, blood contains monomeric IgA. To study the relationship between mucosal and systemic antibody responses, we took advantage of celiac disease patient samples for isolation of gut PCs as well as serum IgA and IgG reactive with a gluten-derived peptide or the autoantigen transglutaminase 2. Proteomic analysis of serum IgA reve ...[more]