Ontology highlight
ABSTRACT:
SUBMITTER: Devarasetty M
PROVIDER: S-EPMC5618030 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Devarasetty Mahesh M Forsythe Steven S Shupe Thomas D TD Soker Shay S Bishop Colin E CE Atala Anthony A Skardal Aleksander A
Biosensors 20170623 3
Organoid and organ-on-a-chip technologies are rapidly advancing towards deployment for drug and toxicology screening applications. Liver and cardiac toxicities account for the majority of drug candidate failures in human trials. Liver toxicity generally produces liver cell death, while cardiac toxicity causes adverse changes in heart beat kinetics. In traditional 2D cultures, beating kinetics can be measured by electrode arrays, but in some 3D constructs, quantifying beating kinetics can be more ...[more]