Ontology highlight
ABSTRACT:
SUBMITTER: Bartoloni M
PROVIDER: S-EPMC5949603 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Bartoloni Marco M Jin Xian X Marcaida Maria José MJ Banha João J Dibonaventura Ivan I Bongoni Swathi S Bartho Kathrin K Gräbner Olivia O Sefkow Michael M Darbre Tamis T Reymond Jean-Louis JL
Chemical science 20150713 10
Double cyclization of short linear peptides obtained by solid phase peptide synthesis was used to prepare bridged bicyclic peptides (BBPs) corresponding to the topology of bridged bicyclic alkanes such as norbornane. Diastereomeric norbornapeptides were investigated by <sup>1</sup>H-NMR, X-ray crystallography and CD spectroscopy and found to represent rigid globular scaffolds stabilized by intramolecular backbone hydrogen bonds with scaffold geometries determined by the chirality of amino acid r ...[more]