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Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N^?-trimethyllysine.

ABSTRACT: N^?-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N^?-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N^?-trimethyllysine.

SUBMITTER: Lesniak RK

PROVIDER: S-EPMC5644716 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine.

Leśniak Robert K RK Markolovic Suzana S Tars Kaspars K Schofield Christopher J CJ

Chemical communications (Cambridge, England) 20161201 2

Nε-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-Nε-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-Nε-trimethyllysine. ...[more]

PMID: 27965989

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