Ontology highlight
ABSTRACT:
SUBMITTER: Lesniak RK
PROVIDER: S-EPMC5644716 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Leśniak Robert K RK Markolovic Suzana S Tars Kaspars K Schofield Christopher J CJ
Chemical communications (Cambridge, England) 20161201 2
N<sup>ε</sup>-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N<sup>ε</sup>-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N<sup>ε</sup>-trimethyllysine. ...[more]