Ontology highlight
ABSTRACT:
SUBMITTER: Vohidov F
PROVIDER: S-EPMC5667506 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Vohidov Farrukh F Knudsen Sarah E SE Leonard Paul G PG Ohata Jun J Wheadon Michael J MJ Popp Brian V BV Ladbury John E JE Ball Zachary T ZT
Chemical science 20150603 8
Src-family kinases (SFKs) play important roles in human biology and are key drug targets as well. However, achieving selective inhibition of individual Src-family kinases is challenging due to the high similarity within the protein family. We describe rhodium(ii) conjugates that deliver both potent and selective inhibition of Src-family SH3 domains. Rhodium(ii) conjugates offer dramatic affinity enhancements due to interactions with specific and unique Lewis-basic histidine residues near the SH3 ...[more]