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Coordination diversity in hydrogen-bonded homoleptic fluoride-alcohol complexes modulates reactivity.

ABSTRACT: The nucleophilic reactivity of fluoride ion is altered in the presence of hydrogen-bond donors, including alcohols. Relatively little is known about the coordination involved; to rectify this, the X-ray structures of fourteen novel fluoride-alcohol complexes with tetrabutylammonium as the counterion have been determined. The coordination number varies from two to four depending on the steric bulk of the alcohol and is closely linked to trends in reactivity. This diversity in coordination stoichiometry is unprecedented but significant, as it implies differences in the ability of the fluoride-alcohol complexes to dissociate in solution with release of a more active and/or selective fluoride source.

SUBMITTER: Engle KM

PROVIDER: S-EPMC5669313 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Coordination diversity in hydrogen-bonded homoleptic fluoride-alcohol complexes modulates reactivity.

Engle Keary M KM Pfeifer Lukas L Pidgeon George W GW Giuffredi Guy T GT Thompson Amber L AL Paton Robert S RS Brown John M JM Gouverneur Véronique V

Chemical science 20150622 9

The nucleophilic reactivity of fluoride ion is altered in the presence of hydrogen-bond donors, including alcohols. Relatively little is known about the coordination involved; to rectify this, the X-ray structures of fourteen novel fluoride-alcohol complexes with tetrabutylammonium as the counterion have been determined. The coordination number varies from two to four depending on the steric bulk of the alcohol and is closely linked to trends in reactivity. This diversity in coordination stoichi ...[more]

PMID: 29449931

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