Ontology highlight
ABSTRACT:
SUBMITTER: Bigliardi PL
PROVIDER: S-EPMC5691209 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20171116 1
A strategy combining covalent conjugation of photosensitizers to a peptide ligand directed to the melanocortin 1 (MC1) receptor with the application of sequential LED light dosage at near-IR wavelengths was developed to achieve specific cytotoxicity to melanocytes and melanoma (MEL) with minimal collateral damage to surrounding cells such as keratinocytes (KER). The specific killing of melanotic cells by targeted photodynamic therapy (PDT) described in this study holds promise as a potentially e ...[more]