Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5696785 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Virology 20150122
A(H3N2) influenza viruses have circulated in humans since 1968, and antigenic drift of the hemagglutinin (HA) protein continues to be a driving force that allows the virus to escape the human immune response. Since the major antigenic sites of the HA overlap into the receptor binding site (RBS) of the molecule, the virus constantly struggles to effectively adapt to host immune responses, without compromising its functionality. Here, we have structurally assessed the evolution of the A(H3N2) viru ...[more]