Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC5907840 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Li Yamu Y Wang Wen W Wang Fangyu F Wu Qiushuang Q Li Wei W Zhong Xiaoling X Tian Kuan K Zeng Tao T Gao Liang L Liu Ying Y Li Shu S Jiang Xiaobing X Du Guangwei G Zhou Yan Y
Journal of molecular cell biology 20170801 4
Glioblastoma multiforme (GBM) is a highly invasive brain tumor with limited therapeutic means and poor prognosis. Recent studies indicate that glioma-initiating cells/glioma stem cells (GICs/GSCs) may be responsible for tumor initiation, infiltration, and recurrence. GICs could aberrantly employ molecular machinery balancing self-renewal and differentiation of embryonic neural precursors. Here, we find that paired related homeobox 1 (PRRX1), a homeodomain transcription factor that was previously ...[more]