Ontology highlight
ABSTRACT:
SUBMITTER: Felsted JA
PROVIDER: S-EPMC5730076 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Felsted Jennifer A JA Chien Cheng-Hao CH Wang Dongqing D Panessiti Micaella M Ameroso Dominique D Greenberg Andrew A Feng Guoping G Kong Dong D Rios Maribel M
Cell reports 20171201 10
The central mechanisms controlling glucose and lipid homeostasis are inadequately understood. We show that α2δ-1 is an essential regulator of glucose and lipid balance, acting in steroidogenic factor-1 (SF1) neurons of the ventromedial hypothalamus (VMH). These effects are body weight independent and involve regulation of SF1<sup>+</sup> neuronal activity and sympathetic output to metabolic tissues. Accordingly, mice with α2δ-1 deletion in SF1 neurons exhibit glucose intolerance, altered lipolys ...[more]