Ontology highlight
ABSTRACT:
SUBMITTER: Williams RM
PROVIDER: S-EPMC5730475 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Williams Ryan M RM Shah Janki J Tian Helen S HS Chen Xi X Geissmann Frederic F Jaimes Edgar A EA Heller Daniel A DA
Hypertension (Dallas, Tex. : 1979) 20171113 1
Direct targeting to the kidneys is a promising strategy to improve drug therapeutic index for the treatment of kidney diseases. We sought to investigate the renal selectivity and safety of kidney-targeted mesoscale nanoparticle technology. We found that direct intravenous administration of these particles resulted in 26-fold renal selectivity and localized negligibly in the liver or other organs. The nanoparticles targeted the renal proximal tubular epithelial cells, as evidenced by intravital m ...[more]