The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease.
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ABSTRACT:
SUBMITTER: Rhoades R
PROVIDER: S-EPMC5744085 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease.
Rhoades Ruben R Gaballa Sameh S
Biomedicines 20171017 4
Chronic graft-versus-host disease (cGVHD) is a leading cause of late morbidity and mortality following allogeneic stem cell transplantation. Current therapies, including corticosteroids and calcineurin inhibitors, are only effective in roughly 50% of cases; therefore, new treatment strategies are under investigation. What was previously felt to be a T cell disease has more recently been shown to involve activation of both T and B cells, as well as a number of cytokines. With a better understandi ...[more]
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