Evidence for B Cell Exhaustion in Chronic Graft-versus-Host Disease.
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ABSTRACT:
SUBMITTER: Khoder A
PROVIDER: S-EPMC5770573 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Evidence for B Cell Exhaustion in Chronic Graft-versus-Host Disease.
Khoder Ahmad A Alsuliman Abdullah A Basar Rafet R Sobieski Catherine C Kondo Kayo K Alousi Amin Majid AM Szydlo Richard R Muftuoglu Muharrem M Shaim Hila H Apperley Jane F JF Gokdemir Elif E Cooper Nichola N Mehta Rohtesh S RS Marin David D Champlin Richard R Shpall Elizabeth E Rezvani Katayoun K
Frontiers in immunology 20180112
Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic hematopoietic stem cell transplantation (HSCT). A number of studies support a role for B cells in the pathogenesis of cGvHD. In this study, we report the presence of an expanded population of CD19+CD21- B cells with features of exhaustion in the peripheral blood of patients with cGvHD. CD21- B cells were significantly increased in patients with active cGvHD compared to patients without cGvHD and healthy controls ...[more]
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