Ontology highlight
ABSTRACT:
SUBMITTER: Smith KS
PROVIDER: S-EPMC5744871 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Smith Kyle S KS Liu Lin L LL Ganesan Shridar S Michor Franziska F De Subhajyoti S
Nature structural & molecular biology 20171002 11
Nuclear organization of genomic DNA affects processes of DNA damage and repair, yet its effects on mutational landscapes in cancer genomes remain unclear. Here we analyzed genome-wide somatic mutations from 366 samples of six cancer types. We found that lamina-associated regions, which are typically localized at the nuclear periphery, displayed higher somatic mutation frequencies than did the interlamina regions at the nuclear core. This effect was observed even after adjustment for features suc ...[more]