Ontology highlight
ABSTRACT:
SUBMITTER: Kim E
PROVIDER: S-EPMC5746612 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Kim Eunhye E Jhun Hyunjhung H Kim Joohee J Park Unjoo U Jo Seunghyun S Kwak Areum A Kim Sinae S Nguyen Tam T TT Kang Yongsun Y Choi Insoo I Lee Joongbok J Kim Heijun H Kim Younghyun Y Lee Siyoung S Kim Soohyun S
Immune network 20171219 6
Interferons (IFNs) have been known as antiviral genes and they are classified by type 1, type 2, and type 3 IFN. The type 1 IFN consists of IFNα, IFNβ, IFNτ, and IFNω whereas the type 2 IFN consists of only IFNγ, which is a key cytokine driving T helper cell type 1 immunity. IFNλ belongs to the type 3 IFN, which is also known as IL-28 and IL-29 possessing antiviral activities. Type 1 IFN is produced by viral infection whereas type 2 IFN is induced by mitogenic or antigenic T-cell stimuli. The IF ...[more]