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Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells.

ABSTRACT: The rationale for the implementation of novel therapies should be based on hallmarks of cancer. Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. We assessed their cytotoxic effect after sensitizing cancer cells with insulin. In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. Both compounds proved to have an antitumor effect which was significantly enhanced in combination with insulin. Linking glucose and anticancer agent presents an approach that exploits the Warburg effect. Targeting dysfunctional glycometabolism and increased glucose absorption is emerging as a promising anticancer strategy.

SUBMITTER: Agrawal S

PROVIDER: S-EPMC5768394 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Insulin and novel thioglycosides exert suppressive effect on human breast and colon carcinoma cells.

Agrawal Siddarth S Wozniak Marta M Luc Mateusz M Walaszek Kinga K Pielka Ewa E Szeja Wieslaw W Pastuch-Gawolek Gabriela G Gamian Andrzej A Ziolkowski Piotr P

Oncotarget 20171211 69

The rationale for the implementation of novel therapies should be based on hallmarks of cancer. Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. We assessed their cytotoxic effect after sensitizing cancer cells with insulin. In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. Both compounds proved to ...[more]

PMID: 29371977

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