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Positioning of proteasome inhibitors in therapy of solid malignancies.

ABSTRACT: Targeting of the protein degradation pathway, in particular, the ubiquitin-proteasome system, has emerged as an attractive novel cancer chemotherapeutic modality. Although proteasome inhibitors have been most successfully applied in the treatment of hematological malignancies, they also received continuing interest for the treatment of solid tumors. In this review, we summarize the current positioning of proteasome inhibitors in the treatment of common solid malignancies (e.g., lung, colon, pancreas, breast, and head and neck cancer), addressing topics of their mechanism(s) of action, predictive factors and molecular mechanisms of resistance.

SUBMITTER: Roeten MSF

PROVIDER: S-EPMC5778165 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Positioning of proteasome inhibitors in therapy of solid malignancies.

Roeten Margot S F MSF Cloos Jacqueline J Jansen Gerrit G

Cancer chemotherapy and pharmacology 20171128 2

Targeting of the protein degradation pathway, in particular, the ubiquitin-proteasome system, has emerged as an attractive novel cancer chemotherapeutic modality. Although proteasome inhibitors have been most successfully applied in the treatment of hematological malignancies, they also received continuing interest for the treatment of solid tumors. In this review, we summarize the current positioning of proteasome inhibitors in the treatment of common solid malignancies (e.g., lung, colon, panc ...[more]

PMID: 29184971

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