Ontology highlight
ABSTRACT:
SUBMITTER: Elena-Real CA
PROVIDER: S-EPMC5840378 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Elena-Real Carlos A CA Díaz-Quintana Antonio A González-Arzola Katiuska K Velázquez-Campoy Adrián A Orzáez Mar M López-Rivas Abelardo A Gil-Caballero Sergio S De la Rosa Miguel Á MÁ Díaz-Moreno Irene I
Cell death & disease 20180306 3
Apoptosis is a highly regulated form of programmed cell death, essential to the development and homeostasis of multicellular organisms. Cytochrome c is a central figure in the activation of the apoptotic intrinsic pathway, thereby activating the caspase cascade through its interaction with Apaf-1. Our recent studies have revealed 14-3-3ε (a direct inhibitor of Apaf-1) as a cytosolic cytochrome c target. Here we explore the cytochrome c / 14-3-3ε interaction and show the ability of cytochrome c t ...[more]