Ontology highlight
ABSTRACT:
SUBMITTER: Dou Z
PROVIDER: S-EPMC5850938 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Dou Zhixun Z Ghosh Kanad K Vizioli Maria Grazia MG Zhu Jiajun J Sen Payel P Wangensteen Kirk J KJ Simithy Johayra J Lan Yemin Y Lin Yanping Y Zhou Zhuo Z Capell Brian C BC Xu Caiyue C Xu Mingang M Kieckhaefer Julia E JE Jiang Tianying T Shoshkes-Carmel Michal M Tanim K M Ahasan Al KMAA Barber Glen N GN Seykora John T JT Millar Sarah E SE Kaestner Klaus H KH Garcia Benjamin A BA Adams Peter D PD Berger Shelley L SL
Nature 20171004 7676
Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a form of terminal cell-cycle arrest associated with pro-inflammatory responses. The functional significance of chromatin in the cytoplasm is unclear. Here we show that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS-ST ...[more]