Ontology highlight
ABSTRACT:
SUBMITTER: Agrawal S
PROVIDER: S-EPMC7485961 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Clinical and translational science 20200409 5
Precise dosing of warfarin is important to achieve therapeutic benefit without adverse effects. Pharmacogenomics explains some interindividual variability in warfarin response, but less attention has been paid to drug-drug interactions in the context of genetic factors. We investigated retrospectively the combined effects of cytochrome P450 (CYP)2C9 and vitamin K epoxide reductase complex (VKORC)1 genotypes and concurrent exposure to CYP2C9-interacting drugs on long-term measures of warfarin ant ...[more]