Ontology highlight
ABSTRACT:
SUBMITTER: Piulats JM
PROVIDER: S-EPMC5882311 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Piulats Jose M JM Kondo Jumpei J Endo Hiroko H Ono Hiromasa H Hagihara Takeshi T Okuyama Hiroaki H Nishizawa Yasuko Y Tomita Yasuhiko Y Ohue Masayuki M Okita Kouki K Oyama Hidejiro H Bono Hidemasa H Masuko Takashi T Inoue Masahiro M
Oncotarget 20180323 22
Individual and small clusters of cancer cells may detach from the edges of a main tumor and invade vessels, which can act as the origin of metastasis; however, the mechanism for this phenomenon is not well understood. Using cancer tissue-originated spheroids, we studied whether disturbing the 3D architecture of cancer spheroids can provoke the reformation process and progression of malignancy. We developed a mechanical disruption method to achieve homogenous disruption of the spheroids while mai ...[more]