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Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate-Carbohydrate Interactions.

ABSTRACT: Carbohydrate-carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate-protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer "gate" enables the lactose moieties to be presented only when an external stimulus is present, mimicking how nature uses enzymes to dynamically regulate glycan expression. Two different carbohydrate-carbohydrate interactions are investigated using this tool.

SUBMITTER: Won S

PROVIDER: S-EPMC5894439 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Triggerable Multivalent Glyconanoparticles for Probing Carbohydrate-Carbohydrate Interactions.

Won Sangho S Hindmarsh Steven S Gibson Matthew I MI

ACS macro letters 20180118 2

Carbohydrate-carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate-protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer "gate" enables the lactose moieties to be presented only when an ext ...[more]

PMID: 29657901

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