Ontology highlight
ABSTRACT:
SUBMITTER: Won S
PROVIDER: S-EPMC5894439 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Won Sangho S Hindmarsh Steven S Gibson Matthew I MI
ACS macro letters 20180118 2
Carbohydrate-carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate-protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer "gate" enables the lactose moieties to be presented only when an ext ...[more]