Dataset Information

Harnessing Qatar Biobank to understand type 2 diabetes and obesity in adult Qataris from the First Qatar Biobank Project.

ABSTRACT: BACKGROUND:Human tissues are invaluable resources for researchers worldwide. Biobanks are repositories of such human tissues and can have a strategic importance for genetic research, clinical care, and future discoveries and treatments. One of the aims of Qatar Biobank is to improve the understanding and treatment of common diseases afflicting Qatari population such as obesity and diabetes. METHODS:In this study we apply a panorama of state-of-the-art statistical methods and machine learning algorithms to investigate associations and risk factors for diabetes and obesity on a sample of 1000 Qatari population. RESULTS:Regarding diabetes, we identified pronounced associations and risk factors in Qatari population including magnesium, chloride, c-peptide of insulin, insulin, and uric acid. Similarly, for obesity, significant associations and risk factors include insulin, c-peptide of insulin, albumin, and uric acid. Moreover, our study has revealed interactions of hypomagnesemia with HDL-C, triglycerides, and free thyroxine. CONCLUSIONS:Our study strongly confirms known associations and risk factors associated with diabetes and obesity in Qatari population as previously found in other population studies in different parts of the world. Moreover, interactions of hypomagnesemia with other associations and risk factors merit further investigations.

SUBMITTER: Ullah E

PROVIDER: S-EPMC5898076 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Harnessing Qatar Biobank to understand type 2 diabetes and obesity in adult Qataris from the First Qatar Biobank Project.

Ullah Ehsan E Mall Raghvendra R Rawi Reda R Moustaid-Moussa Naima N Butt Adeel A AA Bensmail Halima H

Journal of translational medicine 20180412 1

<h4>Background</h4>Human tissues are invaluable resources for researchers worldwide. Biobanks are repositories of such human tissues and can have a strategic importance for genetic research, clinical care, and future discoveries and treatments. One of the aims of Qatar Biobank is to improve the understanding and treatment of common diseases afflicting Qatari population such as obesity and diabetes.<h4>Methods</h4>In this study we apply a panorama of state-of-the-art statistical methods and machi ...[more]

PMID: 29650030

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Project description:BACKGROUND: As countries develop economically, an "epidemiological transition" occurs whereby a set of chronic diseases increasingly becomes a country's health challenge. Against this background, this paper examines the most common conditions associated with the prevalence of diabetes in Qatar, with a specific focus on the diabetes-obesity-hypertension nexus. METHODS: We analyzed data from the World Health Organization's World Health Survey conducted in the State of Qatar in 2006. The survey included demographic, anthropometric, and blood chemistry measurements. Using multivariate logistical regression analysis, we assessed the most common conditions associated with diabetes, using both objective and subjective measures of diabetes. The objective measures relied on random blood sugar tests, and the subjective measure included respondents who affirmatively answered the question on diabetes diagnosis. We repeated our analysis on respondents who had blood glucose levels high enough to be considered diabetic/glucose intolerant but did not answer affirmatively on the question of diabetes diagnosis. RESULTS: WHEN USING THE OBJECTIVE MEASURE OF DIABETES, THE FOLLOWING CONDITIONS APPEARED SIGNIFICANT: obesity (OR?=?1.5, 95% CI?=?1.2 - 1.9), higher income (OR?=?1.4, 95% CI?=?1.0 - 1.9), high cholesterol (OR?=?1.4, 95% CI?=?1.0 - 1.9), having Qatari origin (OR?=?1.3, 95% CI?=?1.0 - 1.7), and increasing systolic blood pressure (SBP) 120-139 mmHg (OR?=?1.5, 95% CI?=?1.2 - 2.0), SBP 140-159 mmHg (OR?=?2.2, 95% CI?=?1.6 - 3.1), SBP?>?160 mmHg (OR?=?3.2, 95% CI?=?2.0 - 5.3). Similar results were obtained using the subjective measure of diabetes as a dependent variable. When applied to the group of respondents that included pre-diabetics and those who did not know they were diabetic, obesity and hypertension appeared as the only statistically significant explanatory variables. CONCLUSION: High prevalence of diabetes, hypertension, and especially obesity is documented among residents of Qatar. Further steps are required to tackle the most common conditions associated with the rising diabetes epidemic in the country, which might also pose significant fiscal challenges in the future.

Project description:This study was designed to quantify the relationship between the absence of heart failure risk factors in middle age and incident heart failure, heart failure-free survival, and overall survival.Quantification of years lived free from heart failure in the context of risk factor burden in mid-life may improve risk communication and prevention efforts.We conducted a pooled, individual-level analysis sampling from communities across the United States as part of 4 cohort studies: the Framingham Heart, Framingham Offspring, Chicago Heart Association Detection Project in Industry, and ARIC (Atherosclerosis Risk In Communities) studies. Participants with and without hypertension (blood pressure ?140/90 mm Hg or treatment), obesity (body mass index ?30 kg/m2), or diabetes (fasting glucose ?126 mg/dl or treatment), and combinations of these factors, at index ages of 45 years and 55 years through 95 years. Competing risk-adjusted Cox models, a modified Kaplan-Meier estimator, and Irwin's restricted mean were used to estimate the association between the absence of risk factors at mid-life and incident heart failure, heart failure-free survival, and overall survival.For participants at age 45 years, over 516,537 person-years of follow-up, 1,677 incident heart failure events occurred. Men and women with no risk factors, compared to those with all 3, had 73% to 85% lower risks of incident heart failure. Men and women without hypertension, obesity, or diabetes at age 45 years lived on average 34.7 years and 38.0 years without incident heart failure, and they lived on average an additional 3 years to 15 years longer free of heart failure than those with 1, 2, or 3 risk factors. Similar trends were seen when stratified by race and at index age 55 years.Prevention of hypertension, obesity, and diabetes by ages 45 years and 55 years may substantially prolong heart failure-free survival, decrease heart failure-related morbidity, and reduce the public health impact of heart failure.

Dataset Information

Harnessing Qatar Biobank to understand type 2 diabetes and obesity in adult Qataris from the First Qatar Biobank Project.

Publications

Harnessing Qatar Biobank to understand type 2 diabetes and obesity in adult Qataris from the First Qatar Biobank Project.

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