Ontology highlight
ABSTRACT:
SUBMITTER: Delgado-Calle J
PROVIDER: S-EPMC5901377 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20180117 5
Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots (caPTH1R<sup>Ot</sup>) and in bones from mice exposed to elevated PTH levels but not in mice lacking [conditional knockout (cKO)] the PTH1R in Ots (cKOPTH1R<sup>Ot</sup>). Furthermore, PTH upregulates ...[more]