Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC5909191 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Xu Jing J Yu Mengxiao M Carter Phoebe P Hernandez Elizabeth E Dang Andrew A Kapur Payal P Hsieh Jer-Tsong JT Zheng Jie J
Angewandte Chemie (International ed. in English) 20170925 43
With more and more engineered nanoparticles (NPs) being designed renal clearable for clinical translation, fundamental understanding of their transport in the different compartments of kidneys becomes increasingly important. Here, we report noninvasive X-ray imaging of renal clearable gold NPs (AuNPs) in normal and nephropathic kidneys. By quantifying the transport kinetics of the AuNPs in cortex, medulla and pelvis of the normal and injured kidneys, we found that ureteral obstruction not just b ...[more]