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Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

ABSTRACT: Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicities against five human cancer cell lines at a concentration of 40 ?M.

SUBMITTER: Zhang H

PROVIDER: S-EPMC5913049 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Two New Indolyl Diketopiperazines, Trypostatins C and D from Aspergillus penicilliodes Speg.

Zhang Han H Zhu Hong-Tao HT Wang Dong D Yang Chong-Ren CR Zhang Ying-Jun YJ

Natural products and bioprospecting 20180314 2

Twelve indolyl diketopiperazines 1-12 were isolated from the mycelia culture of Aspergillus penicilliodes Speg., a dominant microorganism from the post fermentation process of ripe Pu-er tea. Their structures were elucidated by extensive spectroscopic methods. Among them, trypostatins C (1) and D (2) featuring with a rare methyl vinyl ketone side chain at C-2 are new compounds, while 3 and 4 were obtained for the first time from nature source. The isolates 3-12 did not show obvious cytotoxicitie ...[more]

PMID: 29542040

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