Ontology highlight
ABSTRACT:
SUBMITTER: Bonisch M
PROVIDER: S-EPMC5914326 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Bönisch Maximilian M Sellmann Carolin C Maresch Daniel D Halbig Claudia C Becker Stefan S Toleikis Lars L Hock Björn B Rüker Florian F
Protein engineering, design & selection : PEDS 20170901 9
Targeting two unique antigens with a single bispecific antibody is an attractive approach with potential broad therapeutic applicability. However, the production of heterodimeric bispecific antibodies (bsAbs) presents a challenge, requiring the co-expression and accurate pairing of two distinct heavy and light chain units. Several undesirable by-products can be formed in the production process, including heavy chain homodimers and non-cognate light chain pairings. Although additional downstream ...[more]