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Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule.

ABSTRACT: Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.

SUBMITTER: Lin WY

PROVIDER: S-EPMC3131557 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule.

Lin Wan-Yu WY Lu Yi Y Su Jui-Hsin JH Wen Zhi-Hong ZH Dai Chang-Feng CF Kuo Yao-Haur YH Sheu Jyh-Horng JH

Marine drugs 20110609 6

Seven new cembranoids, sarcocrassocolides F-L (1-7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure-activity relationship was studied. Compounds 1-7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression ...[more]

PMID: 21747744

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