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Bioactive cembranoids from the South China Sea soft coral Sarcophyton elegans.

ABSTRACT: Four new cembranoids, sarcophelegans A-D (1-4) and six known analogues (5-10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute conﬁguration of 1 was conﬁrmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1-10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.

SUBMITTER: Liu X

PROVIDER: S-EPMC6331945 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Bioactive cembranoids from the South China Sea soft coral Sarcophyton elegans.

Liu Xin X Zhang Junsheng J Liu Qiao Q Tang Guihua G Wang Hongsheng H Fan Chengqi C Yin Sheng S

Molecules (Basel, Switzerland) 20150722 7

Four new cembranoids, sarcophelegans A-D (1-4) and six known analogues (5-10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute conﬁguration of 1 was conﬁrmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1-10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM. ...[more]

PMID: 26205057

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