Ontology highlight
ABSTRACT:
SUBMITTER: Nangia S
PROVIDER: S-EPMC5928022 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Nangia Shivangi S Pattis Jason G JG May Eric R ER
Journal of biological physics 20180411 2
Flock House virus (FHV) is a well-characterized model system to study infection mechanisms in non-enveloped viruses. A key stage of the infection cycle is the disruption of the endosomal membrane by a component of the FHV capsid, the membrane active γ peptide. In this study, we perform all-atom molecular dynamics simulations of the 21 N-terminal residues of the γ peptide interacting with membranes of differing compositions. We carry out umbrella sampling calculations to study the folding of the ...[more]