Ontology highlight
ABSTRACT:
SUBMITTER: Maddirala AR
PROVIDER: S-EPMC5942382 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20180418
The synthesis of spiro[indoline-3,2'-pyrrole]-2,5'(1'<i>H</i>)-diones and spiro[indoline-3,2'-pyrrolidine]-2,5'-diones, via a post-Ugi-domino transamidation/cyclization sequential process, has been achieved in three sequential steps utilizing a one-pot reaction protocol. The variation in carboxylic acid substrates allows for the generation of new chiral racemic quaternary carbon centers under basic conditions providing molecular diversity and a small library of spirocyclic oxindoles. ...[more]