Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC5943424 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wang Jie J Jia Junqiao J Chen Ran R Ding Shanlong S Xu Qiang Q Zhang Ting T Chen Xiangmei X Liu Shuang S Lu Fengmin F
Cancer medicine 20180330 5
Cytotoxic chemotherapy drugs, including doxorubicin, can directly promote hepatitis B virus (HBV) replication, but the mechanism has not been fully clarified. This study investigated the potential mechanism underlying the cytotoxic chemotherapy-mediated direct promotion of HBV replication. We found that HBV replication and regulatory factor X box 1 gene (RFX1) expression were simultaneously promoted by doxorubicin treatment. The amount of RFX1 bound to the HBV enhancer I was significantly increa ...[more]