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Lamotrigine ethanol monosolvate.

ABSTRACT: Lamotrigine is an active pharmaceutical ingredient used as a treatment for epilepsy and psychiatric disorders. Single crystals of an ethano-late solvate, C9H7Cl2N5·C2H5OH, were produced by slow evaporation of a saturated solution from anhydrous ethanol. Within the crystal structure, the lamotrigine mol-ecules form dimers through N-H?N hydrogen bonds involving the amine N atoms in the ortho position of the triazine group. These dimers are linked into a tape motif through hydrogen bonds involving the amine N atoms in the para position. The ethanol and lamotrigine are present in a 1:1 ratio in the lattice with the ethyl group of the ethanol mol-ecule exhibiting disorder with an occupancy ratio of 0.516?(14):0.484?(14).

SUBMITTER: Hall CL

PROVIDER: S-EPMC5947486 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Lamotrigine ethanol monosolvate.

Hall Charlie L CL Potticary Jason J Sparkes Hazel A HA Pridmore Natalie E NE Hall Simon R SR

Acta crystallographica. Section E, Crystallographic communications 20180419 Pt 5

Lamotrigine is an active pharmaceutical ingredient used as a treatment for epilepsy and psychiatric disorders. Single crystals of an ethano-late solvate, C9H7Cl2N5·C2H5OH, were produced by slow evaporation of a saturated solution from anhydrous ethanol. Within the crystal structure, the lamotrigine mol-ecules form dimers through N-H⋯N hydrogen bonds involving the amine N atoms in the ortho position of the triazine group. Th ...[more]

PMID: 29850090

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