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Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine.

ABSTRACT: Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable ?-chiral allylic amines using benzophenone imine as ammonia carrier.

SUBMITTER: Xu K

PROVIDER: S-EPMC6006468 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine.

Xu Kun K Wang Yu-Hsuan YH Khakyzadeh Vahid V Breit Bernhard B

Chemical science 20160209 5

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier. ...[more]

PMID: 29997823

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