Ontology highlight
ABSTRACT:
SUBMITTER: Anan K
PROVIDER: S-EPMC6009677 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Anan Kotaro K Hino Shinjiro S Shimizu Noriaki N Sakamoto Akihisa A Nagaoka Katsuya K Takase Ryuta R Kohrogi Kensaku K Araki Hirotaka H Hino Yuko Y Usuki Shingo S Oki Shinya S Tanaka Hirotoshi H Nakamura Kimitoshi K Endo Fumio F Nakao Mitsuyoshi M
Nucleic acids research 20180601 11
The metabolic properties of cells are formed under the influence of environmental factors such as nutrients and hormones. Although such a metabolic program is likely initiated through epigenetic mechanisms, the direct links between metabolic cues and activities of chromatin modifiers remain largely unknown. In this study, we show that lysine-specific demethylase-1 (LSD1) controls the metabolic program in myogenic differentiation, under the action of catabolic hormone, glucocorticoids. By using t ...[more]