Ontology highlight
ABSTRACT:
SUBMITTER: Cheeseman MD
PROVIDER: S-EPMC6014687 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Cheeseman Matthew D MD Chessum Nicola E A NE Rye Carl S CS Pasqua A Elisa AE Tucker Michael J MJ Wilding Birgit B Evans Lindsay E LE Lepri Susan S Richards Meirion M Sharp Swee Y SY Ali Salyha S Rowlands Martin M O'Fee Lisa L Miah Asadh A Hayes Angela A Henley Alan T AT Powers Marissa M Te Poele Robert R De Billy Emmanuel E Pellegrino Loredana L Raynaud Florence F Burke Rosemary R van Montfort Rob L M RL Eccles Suzanne A SA Workman Paul P Jones Keith K
Journal of medicinal chemistry 20161222 1
Phenotypic screens, which focus on measuring and quantifying discrete cellular changes rather than affinity for individual recombinant proteins, have recently attracted renewed interest as an efficient strategy for drug discovery. In this article, we describe the discovery of a new chemical probe, bisamide (CCT251236), identified using an unbiased phenotypic screen to detect inhibitors of the HSF1 stress pathway. The chemical probe is orally bioavailable and displays efficacy in a human ovarian ...[more]