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Illuminating pathogen-host intimacy through optogenetics.

ABSTRACT: The birth and subsequent evolution of optogenetics has resulted in an unprecedented advancement in our understanding of the brain. Its outstanding success does usher wider applications; however, the tool remains still largely relegated to neuroscience. Here, we introduce selected aspects of optogenetics with potential applications in infection biology that will not only answer long-standing questions about intracellular pathogens (parasites, bacteria, viruses) but also broaden the dimension of current research in entwined models. In this essay, we illustrate how a judicious integration of optogenetics with routine methods can illuminate the host-pathogen interactions in a way that has not been feasible otherwise.

SUBMITTER: Arroyo-Olarte RD

PROVIDER: S-EPMC6042787 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Illuminating pathogen-host intimacy through optogenetics.

Arroyo-Olarte Ruben Dario RD Thurow Laura L Kozjak-Pavlovic Vera V Gupta Nishith N

PLoS pathogens 20180712 7

The birth and subsequent evolution of optogenetics has resulted in an unprecedented advancement in our understanding of the brain. Its outstanding success does usher wider applications; however, the tool remains still largely relegated to neuroscience. Here, we introduce selected aspects of optogenetics with potential applications in infection biology that will not only answer long-standing questions about intracellular pathogens (parasites, bacteria, viruses) but also broaden the dimension of c ...[more]

PMID: 30001435

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