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Precise modulation of embryonic development through optogenetics.

ABSTRACT: The past decade has witnessed enormous progress in optogenetics, which uses photo-sensitive proteins to control signal transduction in live cells and animals. The ever-increasing amount of optogenetic tools, however, could overwhelm the selection of appropriate optogenetic strategies. In this work, we summarize recent progress in this emerging field and highlight the application of opsin-free optogenetics in studying embryonic development, focusing on new insights gained into optical induction of morphogenesis, cell polarity, cell fate determination, tissue differentiation, neuronal regeneration, synaptic plasticity, and removal of cells during development.

SUBMITTER: Fan H

PROVIDER: S-EPMC9847014 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Precise modulation of embryonic development through optogenetics.

Fan Huaxun H Barnes Collin C Hwang Hyojeong H Zhang Kai K Yang Jing J

Genesis (New York, N.Y. : 2000) 20221207 10-12

The past decade has witnessed enormous progress in optogenetics, which uses photo-sensitive proteins to control signal transduction in live cells and animals. The ever-increasing amount of optogenetic tools, however, could overwhelm the selection of appropriate optogenetic strategies. In this work, we summarize recent progress in this emerging field and highlight the application of opsin-free optogenetics in studying embryonic development, focusing on new insights gained into optical induction o ...[more]

PMID: 36478118

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