Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes.
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ABSTRACT:
SUBMITTER: Naret O
PROVIDER: S-EPMC6078058 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Correcting for Population Stratification Reduces False Positive and False Negative Results in Joint Analyses of Host and Pathogen Genomes.
Naret Olivier O Chaturvedi Nimisha N Bartha Istvan I Hammer Christian C Fellay Jacques J
Frontiers in genetics 20180730
Studies of host genetic determinants of pathogen sequence variations can identify sites of genomic conflicts, by highlighting variants that are implicated in immune response on the host side and adaptive escape on the pathogen side. However, systematic genetic differences in host and pathogen populations can lead to inflated type I (false positive) and type II (false negative) error rates in genome-wide association analyses. Here, we demonstrate through a simulation that correcting for both host ...[more]
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