MTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3⁺ Regulatory T Cells.

ABSTRACT: The mechanistic/mammalian target of rapamycin (mTOR) has emerged as a critical integrator of signals from the immune microenvironment capable of regulating T cell activation, differentiation, and function. The precise role of mTOR in the control of regulatory T cell (Treg) differentiation and function is complex. Pharmacologic inhibition and genetic deletion of mTOR promotes the generation of Tregs even under conditions that would normally promote generation of effector T cells. Alternatively, mTOR activity has been observed to be increased in Tregs, and the genetic deletion of the mTOR complex 1 (mTORC1)-scaffold protein Raptor inhibits Treg function. In this study, by employing both pharmacologic inhibitors and genetically altered T cells, we seek to clarify the role of mTOR in Tregs. Ou

SUBMITTER: Sun IH 

PROVIDER: S-EPMC6089237 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature