Ontology highlight
ABSTRACT:
SUBMITTER: Cheng H
PROVIDER: S-EPMC7477744 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cheng Hao H Wang Lingbiao L Yang Biaolong B Li Dan D Wang Xiaoxia X Liu Xinnan X Tian Na N Huang Qianru Q Feng Ru R Wang Zhengting Z Liang Rui R Dai Sheng-Ming SM Lv Ling L Wu Ji J Zang Yuan-Sheng YS Li Bin B
Journal of immunology (Baltimore, Md. : 1950) 20200819 6
IL-10 is critical for Foxp3<sup>+</sup> regulatory T cell (Tregs)-mediated immune suppression, but how to efficiently upregulate IL-10 production in Tregs remains unclear. In this article, we show that human IL-10<sup>+</sup> FOXP3<sup>+</sup>-induced regulatory T cell (iTreg) generation can be dramatically promoted by inhibiting GSK3 activity. IL-10<sup>+</sup> FOXP3<sup>+</sup> iTregs induced by GSK3 inhibition exhibit classical features of immune-suppressive T cells. We further demonstrate th ...[more]