Ontology highlight
ABSTRACT:
SUBMITTER: Bishop DC
PROVIDER: S-EPMC6094355 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Bishop David C DC Xu Ning N Tse Benjamin B O'Brien Tracey A TA Gottlieb David J DJ Dolnikov Alla A Micklethwaite Kenneth P KP
Molecular therapy : the journal of the American Society of Gene Therapy 20180601 8
Clinical trials of CD19-specific chimeric antigen receptor (CAR19) T cells have demonstrated remarkable efficacy against relapsed and refractory B cell malignancies. The piggyBac transposon system offers a less complex and more economical means for generating CAR19 T cells compared to viral vectors. We have previously optimized a protocol for the generation of CAR19 T cells using the piggyBac system, but we found that CAR19 T cells had poor in vivo efficacy and persistence, probably due to delet ...[more]