Ontology highlight
ABSTRACT:
SUBMITTER: Manni M
PROVIDER: S-EPMC6095139 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Manni Michela M Gupta Sanjay S Ricker Edd E Chinenov Yurii Y Park Sung Ho SH Shi Man M Pannellini Tania T Jessberger Rolf R Ivashkiv Lionel B LB Pernis Alessandra B AB
Nature immunology 20180226 4
Age-associated B cells (ABCs) are a subset of B cells dependent on the transcription factor T-bet that accumulate prematurely in autoimmune settings. The pathways that regulate ABCs in autoimmunity are largely unknown. SWAP-70 and DEF6 (also known as IBP or SLAT) are the only two members of the SWEF family, a unique family of Rho GTPase-regulatory proteins that control both cytoskeletal dynamics and the activity of the transcription factor IRF4. Notably, DEF6 is a newly identified human risk var ...[more]