Ontology highlight
ABSTRACT:
SUBMITTER: Gimenez-Navarro V
PROVIDER: S-EPMC6102595 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20180504 5
We report two synthetic strategies for traceless solid-phase synthesis of molecular scaffolds comprising 6- to 8-membered rings fused with 5- to 7-membered rings. Traceless synthesis facilitated preparation of target molecules without any trace of polymer-supported linkers. The cyclization proceeded via acid-mediated tandem <i>N</i>-acylium ion formation followed by the nucleophilic addition of <i>O</i>- and <i>C</i>-nucleophiles. The presented synthetic strategy enabled, through the use of simp ...[more]